SET1 — Saccharomyces cerevisiae S288c

Summary

YHR119W (SET1) on chromosome VIII of Saccharomyces cerevisiae encodes a protein with histone H3K4 trimethylase and methylase activities, as well as RNA binding and methyltransferase activity. The protein contains SET, post-SET, and COMPASS-associated domains. SET1 is associated with telomere capping and maintenance, telomeric silencing, sterol homeostasis, meiotic DNA double-strand break formation, meiosis I, cell cycle control, DNA damage checkpoint, nuclear export, and responses to diamide, oleate, and xenobiotic stimuli. It localizes to chromosomes and telomeric regions. Phenotypic associations include decreased telomere length, silencing, replicative lifespan, competitive fitness, viability, and gamma ray resistance, increased flocculation and fermentative metabolism, abnormal cell wall and endomembrane system morphology, and absent sporulation and protein/peptide modification. Studies of related genes in other species link the family to reduced virulence and oxidative stress.