PDR11 — Saccharomyces cerevisiae S288c

Summary

YIL013C, also known as SNQ2 or PDR11, encodes an ABC-type xenobiotic transporter with ATP-coupled transmembrane transporter activity and ATP hydrolase activity, localised to the plasma membrane. The gene is associated with sterol import, intracellular sterol transport, sterol homeostasis, and sterol anabolism, as well as responses to xenobiotic and antibiotic stimuli, cellular detoxification, lipid oxidation, and quorum sensing. It is linked to progesterone, lycopene, and nucleotide anabolism, amino acid breakdown, demethylation, immune system development, and system development. Phenotypic associations include decreased filamentous growth, absent invasive growth, decreased chemical compound accumulation, increased competitive fitness, abnormal vacuolar morphology, and decreased resistance to chemicals. The gene is also linked to salt tolerance and oxidative stress traits. Related genes in other species further connect the family to multidrug resistance and detoxification processes.