HOP1 — Saccharomyces cerevisiae S288c

Summary

YIL072W (HOP1) on chromosome IX of Saccharomyces cerevisiae S288c encodes a HORMA-domain protein of the Hop1 family. The gene is associated with meiotic cell cycle progression, including homologous chromosome pairing, sister chromatid cohesion, and meiotic chromosome condensation. It is linked to DNA condensation, double-strand break repair, and the suppression of meiotic recombination. HOP1 is associated with prophase stages such as leptotene, zygotene, and diakinesis, as well as anaphase and sister chromatid segregation. Phenotypic associations include decreased meiotic recombination and spore germination, reduced sporulation efficiency, abnormal vegetative growth, and increased innate thermotolerance. The gene is also linked to decreased chronological lifespan, altered competitive fitness, and resistance to chemicals.