SEC24 — Saccharomyces cerevisiae S288c

Summary

YIL109C (SEC24) on chromosome IX of Saccharomyces cerevisiae S288c encodes a protein that binds signal sequences and SNAREs, and contains a zinc-finger domain characteristic of the Sec23/Sec24 subfamily. SEC24 is associated with cargo selection and loading into COPII vesicles, vesicle scission, ER-to-Golgi transport, and positive regulation of protein exit from the ER. It has been linked to macroautophagy, cell death, spindle organization, microtubule assembly, rRNA transcription, RNA breakdown, and regulation of cell growth. The protein localizes to ER exit sites, the COPII vesicle coat, the cis-Golgi network, and the ER and Golgi membranes. Associations with oxidative stress, increased innate thermotolerance, decreased toxin resistance, altered endomembrane and ER morphology, decreased autophagy, reduced vegetative growth, and altered chemical resistance have been noted.