UBP7 — Saccharomyces cerevisiae S288c

Summary

YIL156W in Saccharomyces cerevisiae S288c encodes a metal-dependent deubiquitinase with thiol-dependent deubiquitinase activity, membrane destabilizing activity, and lipid binding. The protein belongs to the mitofissin and ubiquitin carboxyl-terminal hydrolase families. It is associated with membrane fission, mitochondrial fission, ESCRT III complex assembly, mitophagy, ubiquitin recycling, and free ubiquitin chain depolymerization. The gene is linked to regulation of clathrin-mediated endocytosis, ATP export, and ubiquitin-dependent protein catabolism via the MVB pathway. It localizes to the late endosome membrane, endosome, cytoplasm, cytosol, ER, and cellular bud neck. Associations include increased prion formation, abnormal mitochondrial and vacuolar morphology, decreased mitophagy, decreased competitive fitness, and altered resistance to toxins, metals, and chemicals. Related genes in other species link the family to ubiquitin-specific protease activity (EC 3.4.19.12).