BNR1 — Saccharomyces cerevisiae S288c

Summary

YIL159W, also known as BNI1 or BNR1, encodes a formin-family protein in Saccharomyces cerevisiae S288c on chromosome IX. The product binds SH3 domains, F-BAR domains, cytoskeletal proteins, F-actin, and small GTPases. It is associated with actin nucleation, filament capping, cell polarization, cytokinesis, spindle orientation and assembly, bud site selection, and protein localization to the contractile ring. The protein localizes to the bud tip, bud neck, mating projection, hyphal tip, and actomyosin ring. The gene is linked to abnormal actin cytoskeleton and bud morphology, decreased vegetative growth and chronological lifespan, increased heat sensitivity, altered nuclear transport and vacuolar morphology, and increased oxidative stress resistance. It is also associated with oxidative stress. Studies of related genes in other species link the family to cell fusion and cytokinesis.