IKS1 — Saccharomyces cerevisiae S288c

Summary

YJL057C, also known as ATG1 or IKS1 in Saccharomyces cerevisiae S288c on chromosome X, encodes a protein with protein serine/threonine kinase activity and ATP binding. The gene is associated with regulation of protein binding, chaperone-mediated autophagy, detoxification of hydrogen peroxide, reactive oxygen species anabolism, autophagy of peroxisome, pexophagy, cellular response to nutrient, carbohydrate storage, proteaphagy, aggrephagy, glucose homeostasis, conidiophore development, externalization of phosphatidylserine, microlipophagy, cellular response to K+ ion starvation, cytoplasm to vacuole targeting by the Cvt pathway, Cvt vesicle assembly, and response to zinc. It is linked to traits including nitrogen content and oxidative stress, and to phenotypes such as decreased starvation resistance, decreased chronological lifespan, decreased UV and metal resistance, abnormal vacuolar morphology, and altered competitive fitness. The protein localizes to the vacuole-IM contact site, phagophore, PAS membrane, and cytosol.