GSH1 — Saccharomyces cerevisiae S288c

Summary

YJL101C (GCS1/GSH1) on chromosome X of Saccharomyces cerevisiae S288c encodes a protein with glutamate-cysteine ligase activity and ATP binding. The gene is associated with glutathione metabolism and anabolism, as well as the regulation of glutathione anabolism. It is linked to responses to cadmium, mercury, acetaldehyde, and oxidative stress, along with methylglyoxal metabolism and breakdown. Associations with cellular respiration, the electron transport chain, and respiration rate have been observed, as well as with iron concentration and light sensitivity. Phenotypic connections include decreased respiratory growth, increased cell death, reduced chronological lifespan, altered stress resistance, and changes in colony color, cell size, and budding index. The encoded protein localizes to the cytoplasm, cytosol, nucleus, and the glutamate-cysteine ligase complex.