INO1 — Saccharomyces cerevisiae S288c

Summary

YJL153C, also known as INO1, encodes inositol-3-phosphate synthase in Saccharomyces cerevisiae S288c on chromosome X. The gene is associated with inositol anabolism and its regulation, as well as PtdIns biosynthesis and catabolism, membrane lipid anabolism, and phosphatidylserine anabolism. INO1 has been linked to triglyceride homeostasis and metabolism, unsaturated fatty acid anabolism, PKC activation and signal transduction, desumoylation, and NO storage. The encoded protein localizes to the cytoplasm and hyphal cell wall. Associations with traits include proline content and oxidative stress. Phenotypic associations link INO1 to increased viability and competitive fitness, but decreased resistance to osmotic stress, oxidative stress, UV, heat, desiccation, and starvation, as well as reduced respiratory growth, vegetative growth rate, endocytosis, and carbon source utilization. Related genes in other species place the family within EC 5.5.1.4.