CBF1 — Saccharomyces cerevisiae S288c

Summary

YJR060W, also known as CBF1, is a gene on chromosome X of Saccharomyces cerevisiae S288c. It encodes a DNA-binding transcription factor with RNA polymerase II-specific activity and protein dimerization activity, belonging to the bHLHzip_scCBP1-like family. CBF1 is associated with a wide range of biological processes, including cold acclimation, regulation of gene expression, sulfur amino acid metabolism, and glutathione anabolism. It is linked to traits such as sulfur content and oxidative stress. The gene product localizes to the nucleus and the centromere complex. Phenotypic associations include abnormal chromosome segregation, altered cell cycle progression, increased innate thermotolerance, and changes in oxidative stress resistance and vegetative growth.