CSE4 — Saccharomyces cerevisiae S288c

Summary

YKL049C, also known as CSE4, is located on chromosome XI of Saccharomyces cerevisiae S288c and encodes a protein that is a structural constituent of chromatin. The gene product binds centromeric DNA, exhibits protein heterodimerization activity, and localizes to the centromeric core domain, kinetochore, and CENP-A-containing chromatin. CSE4 is associated with kinetochore assembly, centromere localization and clustering, mitotic spindle checkpoint, and cell cycle progression through metaphase and M phase. It is linked to chromosome segregation, plasmid partitioning, heterochromatin organization, and proteolysis. Phenotypic associations include abnormal chromosome segregation, metaphase arrest, decreased autophagy and vegetative growth, altered chemical resistance, and inviability.