STE3 — Saccharomyces cerevisiae S288c

Summary

YKL178C (STE3) in Saccharomyces cerevisiae S288c encodes a G-protein-coupled receptor (GPCR) of the STE3 family, with mating-type a-factor pheromone receptor activity. The gene is associated with the pheromone response MAPK cascade, signal transduction, receptor recycling, and receptor-mediated endocytosis. It is linked to TOR signaling, response to carbon dioxide, bioluminescence, and regulation of carbohydrate anabolism. The protein localizes to the plasma membrane, particularly at the cell tip, and also to the nucleus. Phenotypic associations include altered mating response, decreased pheromone-induced cell cycle arrest, increased autophagy, increased chronological lifespan, decreased heat sensitivity, decreased metal resistance, and decreased vegetative growth rate. Studies of related genes in other species link the family to additional cellular processes.