SSA2 — Saccharomyces cerevisiae S288c

Summary

YLL024C (SSA2) on chromosome XII of Saccharomyces cerevisiae S288c encodes an ATP-dependent protein folding chaperone of the Hsp70 family, possessing ATP hydrolase activity, peptide binding, unfolded protein binding, and heat shock protein binding functions, and also acts as a transcriptional co-regulator. The gene is associated with protein folding, protein denaturation, exosome biogenesis, translation termination, biofilm formation, invasive growth, endocytosis, cell communication, regulation of phosphorylation, and response to toxic substances. It localizes to the fungal-type cell wall, hyphal cell wall, yeast-form cell wall, fungal biofilm matrix, plasma membrane, protein aggregate center, and extracellular space. Associations include decreased biofilm formation, increased invasive growth, altered thermotolerance, decreased stress resistance, decreased toxin resistance, decreased competitive fitness, and increased protein accumulation. Related genes in other species are linked to general chaperone functions.