UBR2 — Saccharomyces cerevisiae S288c

Summary

YLR024C, also known as UBR2, is a ubiquitin ligase with zinc-binding activity located in the cytoplasm, nucleus, and ubiquitin ligase complex. It is associated with the N-end rule pathway of ubiquitin-dependent protein breakdown, as well as GDP and ergosterol anabolism, glycerol breakdown, folate biosynthesis, DNA damage response, peptide transport, detoxification, nucleophagy, chromosome division, meiosis, mitosis, sporulation, innate immunity, and negative regulation of the SREBP signaling pathway. The gene is linked to increased stress resistance, altered magnesium content, and increased lifespan, replicative lifespan, competitive fitness, and sporulation efficiency, alongside decreased toxin resistance and carbon source utilization. Studies of related genes in other species link the family to RING-type E3 ubiquitin transferase activity (EC 2.3.2.27).