ERG3 — Saccharomyces cerevisiae S288c

Summary

YLR056W (ERG3) in Saccharomyces cerevisiae S288c encodes a sterol-C5-desaturase with lathosterol oxidase activity, an iron-binding enzyme that localises to the endoplasmic reticulum membrane and lumen, as well as the Golgi complex and plasma membrane. This gene is associated with ergosterol, sterol and lipid metabolism, and has been connected to sterol homeostasis, response to sterol and oxidative stress, mitochondrial biogenesis, oxidative phosphorylation, filamentous growth, and phototropism. It is linked to traits including potassium concentration, calcium sensitivity, oxidative stress, light sensitivity, and acid sensitivity. Phenotypic associations include abnormal plasma membrane and ER morphology, increased cell death and biofilm formation, decreased cell size, invasive growth, endocytosis, and resistance to acid, UV, hyperosmotic stress, and oxidative stress, as well as altered carbon and nitrogen source utilisation and respiratory growth.