ACE2 — Saccharomyces cerevisiae S288c

Summary

YLR131C (ACE2) in Saccharomyces cerevisiae S288c on chromosome XII encodes a DNA-binding transcription activator with RNA polymerase II-specific activity and a C2H2-type zinc-finger domain. It is associated with 14-3-3 protein binding and localizes to chromatin, cytoplasm, cytosol, and nucleus. ACE2 is associated with cell cycle control, mitotic cell cycle, G1 phase, septum digestion after cytokinesis, bipolar bud site selection, cell size control, polar cell growth, pseudohyphal growth, biofilm formation, ethanol fermentation, calcium signaling, peptide secretion, and negative regulation of signaling. It is associated with increased cell size, decreased replicative lifespan, abnormal budding pattern, altered stress resistance including increased oxidative stress resistance and decreased heat sensitivity, abnormal colony and vacuolar morphology, and changes in competitive fitness. Related genes in other species are linked to virulence and pathogenicity.