ECM22 — Saccharomyces cerevisiae S288c

Summary

YLR228C, also known as UPC2 or ECM22, encodes a DNA-binding transcription factor specific for RNA polymerase II, belonging to the Zn2-C6 fungal-type transcription factor family. Located in the nucleus, this Saccharomyces cerevisiae S288c gene on chromosome XII is associated with the regulation of sterol import, response to sterol depletion, and ergosterol biosynthesis. It is linked to lipid homeostasis, cholesterol import, and isoprenoid metabolism, as well as invasive and filamentous growth. Phenotypic associations include increased chronological lifespan, increased stress resistance, and altered cell size and morphology. The gene is also associated with pyroptotic cell death, response to anoxia, and terpene biosynthesis. Studies of related genes in other species link the family to reduced virulence.