ATG17 — Saccharomyces cerevisiae S288c

Summary

YLR423C (ATG17) on chromosome XII of Saccharomyces cerevisiae S288c encodes a protein with protein kinase activator activity and SNARE binding, and contains an ATG17-like domain. The gene is associated with macroautophagy, mitophagy, nucleophagy, micropexophagy, and Cvt vesicle assembly, as well as vacuole fusion, membrane fusion, and protein localization to the phagophore assembly site (PAS). It is linked to responses to starvation and nutrient levels, and to filamentous growth and cytokinesis. The protein localizes to the PAS, the PAS membrane, and vacuole–IM contact sites. ATG17 is associated with decreased autophagy, mitophagy, pexophagy, and ribophagy; absent late nucleophagy; increased cell size and telomere length; decreased sporulation efficiency, replicative lifespan, and stress resistance; and abnormal nuclear and bud morphology. Related genes in other species link it to the ULK complex.