PIF1 — Saccharomyces cerevisiae S288c

Summary

YML061C, the PIF1 gene of Saccharomyces cerevisiae S288c, encodes a protein with DNA helicase activity, 5'-3' DNA helicase activity, G4 unwinding activity, DNA reannealing activity, 3'-5' exonuclease activity, ATP-dependent protein-DNA complex displacement activity, telomerase inhibitor activity, flap-structured DNA binding, G-DNA binding, telomere binding, centromere binding, ssDNA binding, and ssDNA-dependent ATPase activity. YML061C is associated with telomere assembly and maintenance, negative regulation of telomere maintenance via telomerase, upregulation of DNA repair, bypass DNA synthesis, meiotic DNA repair synthesis, R-loop processing, Okazaki fragment processing, DNA replication termination, double-strand break repair, sister chromatid cohesion, mitochondrial genome maintenance, group II intron splicing, and the DNA damage checkpoint. It localises to the nuclear replisome, nuclear replication fork, chromosome telomeric repeat region, rDNA heterochromatin, nucleolus, chromatin, and mitochondria. The gene is linked to increased telomere length, increased mutation frequency, decreased chronological lifespan, altered stress resistance, and changes in respiratory and vegetative growth.