TUB1 — Saccharomyces cerevisiae S288c

Summary

YML085C (TUB2) in Saccharomyces cerevisiae S288c encodes a protein that is a structural constituent of the cytoskeleton with GTP-binding and hydrolase activity. The gene is associated with microtubule assembly, spindle positioning, mitotic checkpoint control, metaphase chromosome alignment, and nuclear migration via microtubule-mediated pushing forces. It is also linked to ER inheritance, cytoplasmic microtubule organization, secretion, endocytosis, and cell cycle progression. The protein localizes to the tubulin complex, kinetochore and astral microtubules, spindle, and cytoplasm. Phenotypic associations include abnormal cytoskeleton and spindle morphology, decreased growth rate, increased cold and heat sensitivity, altered protein accumulation, and inviability. Related genes in other species link the family to epsilon-tubulin domains and V-ATPase subunits.