TUB3 — Saccharomyces cerevisiae S288c

Summary

YML124C in Saccharomyces cerevisiae S288c encodes a protein annotated as a structural constituent of the cytoskeleton with GTP-binding and hydrolase activity. The gene is associated with microtubule-based processes including spindle assembly, metaphase chromosome alignment, anaphase, chromosome separation, and nuclear migration via microtubule-mediated pushing forces. It is linked to mitotic spindle positioning, cytoplasmic microtubule organization, microtubule destabilization, ER inheritance, secretion, chromatin modeling, meiotic prophase I, centromere localization, and morphogenesis. The protein localizes to the tubulin complex, kinetochore microtubules, astral microtubules, spindle, spindle microtubules, cytoplasmic microtubules, cytoplasm, cytosol, and nucleus. Associations with increased oxidative stress resistance, increased innate thermotolerance, altered vegetative growth rates, and changes in competitive fitness have been observed. Studies of related genes in other species link the family to microtubule dynamics and cell division processes.