MYO5 — Saccharomyces cerevisiae S288c

Summary

YMR109W (MYO1) in Saccharomyces cerevisiae S288c encodes a microfilament motor protein with ATP binding, hydrolase activity, F-actin binding, and Arp2/3 complex binding. The protein localises to the actin cytoskeleton, actin patches, the myosin I complex, and the cell cortex. MYO1 is associated with endocytosis, pinocytosis, membrane invagination and bending, vesicle scission, actin polymerisation and its regulation, cell polarisation, mitotic cytokinesis, ER-phagy, and the response to starvation. Associations with turgor pressure and potassium concentration have been noted. Phenotypic associations include decreased bipolar budding, abnormal budding, decreased endocytosis and reticulophagy, increased cold and heat sensitivity, increased killer toxin and chemical resistance, increased replicative lifespan, and decreased vegetative growth rate and competitive fitness. Studies of related genes in other species link the family to similar actin-based processes.