CAT8 — Saccharomyces cerevisiae S288c

Summary

YMR280C in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor with specificity for RNA polymerase II, containing a Zn2-C6 fungal-type DNA-binding domain. This nuclear protein is associated with the regulation of gluconeogenesis, the glyoxylate cycle, the TCA cycle, fatty acid oxidation, the carnitine shuttle, and carbon catabolite repression. It has been linked to hexose anabolism, heterotrophy, fermentation, quorum sensing, energy homeostasis, sporulation, cell wall thickening, and responses to salt and oxidative stress. Phenotypic associations include decreased respiratory metabolism and growth, decreased sporulation efficiency, decreased chronological lifespan, altered metal and chemical resistance, decreased UV and desiccation resistance, and abnormal vacuolar morphology. The gene is related to CAT8, and related genes in other species are linked to stress response regulation.