SIS1 — Saccharomyces cerevisiae S288c

Summary

YNL007C (JJJ1) in Saccharomyces cerevisiae S288c encodes a J-domain protein of the DnaJ/HSP40 family, with ATP binding, unfolded protein binding, Hsp70 protein binding, and protein sequestering activity. The gene product is associated with protein quality control, including protein aggregate center assembly, SG disassembly, protein denaturation and refolding, and the cellular response to unfolded proteins. It has been linked to negative regulation of drug response, mRNA stabilization, chromatin modeling, secretion, mitochondrial outer membrane protein import, peroxisome matrix protein import, cell division, and regulation of phospholipid anabolism. Localization evidence connects the protein to the protein aggregate center, ER lumen and membrane, mitochondrial inner membrane, cytoplasm, cytosol, cell tip, and cell division site. Phenotypic associations include increased heat sensitivity, altered prion inheritance, increased toxin resistance, decreased vegetative growth, and changes in competitive fitness and chemical resistance.