YDJ1 — Saccharomyces cerevisiae S288c

Summary

YDJ1 (YNL064C) of Saccharomyces cerevisiae S288c on chromosome XIV encodes a DnaJ/Hsp40 family chaperone with protein sequestering activity, Hsp70 protein binding, unfolded protein binding, zinc binding, and ATP binding. This gene is associated with protein folding, the ERAD pathway, protein import, ribosome assembly, mitochondrial biogenesis, cell wall biogenesis, prenylation, RNA metabolism, translation initiation, viral translation, stress granule disassembly, invasive growth, and memory. It is linked to responses to heat and yeast, and to negative regulation of response to drug. The protein localizes to the cytoplasm, ER lumen and membrane, mitochondria, mitochondrial inner membrane, cell tip, cell division site, and protein aggregate centers. Associations with traits include potassium concentration, oxidative stress, light sensitivity, and acid sensitivity. Phenotypic connections include altered stress resistance, thermotolerance, chronological lifespan, mating efficiency, cell size, colony shape, and carbon/nitrogen source utilization.