TOM70 — Saccharomyces cerevisiae S288c

Summary

YNL121C (TOM70) on chromosome XIV of Saccharomyces cerevisiae S288c encodes a mitochondrial outer membrane translocase with ATPase inhibitor activity, Hsp90 binding, and mitochondrion targeting sequence binding functions. It is a component of the TOM complex and is associated with protein import, mitochondrial biogenesis, translation initiation, antiviral response, cell death, autophagy, mitochondrial fission and distribution, phospholipid and sphingolipid homeostasis, ATP anabolism, amino acid breakdown, and memory. The gene is linked to abnormal mitochondrial morphology and transport, absent respiratory metabolism, petite-negative phenotype, decreased biofilm formation and invasive growth, altered replicative and chronological lifespan, increased stress resistance, decreased starvation and desiccation resistance, increased heat sensitivity, and abnormal vacuolar morphology. It contains TPR repeats and a UCS central domain.