ALP1 — Saccharomyces cerevisiae S288c

Summary

YNL270C in Saccharomyces cerevisiae S288c encodes a basic amino acid permease with L-histidine, L-arginine, and L-lysine transmembrane transporter activity, as well as amino acid binding. This plasma membrane protein is associated with arginine and proline metabolism, lysine and fatty acid transport, SAM transport, uracil anabolism, exocyst assembly, plasmid recombination, and responses to doxorubicin and actidione. It has been linked to oxidative stress, heat sensitivity, decreased starvation resistance, reduced nitrogen source utilization, decreased vegetative growth rate, abnormal chemical compound accumulation, increased competitive fitness, and altered chemical resistance. The protein localizes to the eisosome, extracellular vesicle, fungal-type cell wall, and membrane. Studies of related genes in other species connect the family to additional amino acid transport functions.