RPD3 — Saccharomyces cerevisiae S288c

Summary

YNL330C (RPD3) on chromosome XIV of Saccharomyces cerevisiae encodes a histone deacetylase with activity toward multiple histone residues, including H3-K9, H3-K14, H4-K5, H4-K8, H4-K12, and H4-K16, and also possesses protein deacetylase and chromatin-binding activities. The gene is associated with the regulation of gene expression, DNA repair, nucleosome assembly, telomeric silencing, sexual reproduction, and responses to oxidative stress, heat, and hydrogen peroxide. It is linked to traits such as nickel content, UV light sensitivity, sporogenesis, potassium uptake, and oxidative stress. Phenotypic associations include increased autophagy, altered silencing, decreased mating efficiency, increased replicative lifespan, increased osmotic stress resistance, and decreased vegetative growth. The product localizes to several chromatin-modifying complexes, including the Rpd3S, HDA1, SHREC, and SET3C complexes, as well as euchromatin and heterochromatin regions.