SMC5 — Saccharomyces cerevisiae S288c

Summary

YOL034W (SMC5) on chromosome XV of Saccharomyces cerevisiae S288c encodes a structural maintenance of chromosomes protein that is a core component of the Smc5-Smc6 complex. The product possesses ssDNA binding and ATP hydrolase activity. SMC5 is associated with mitotic chromosome segregation, sister chromatid cohesion, chromatin looping, centromere separation, anaphase, metaphase, S phase, and mitotic exit. It is linked to DNA replication, the DNA damage checkpoint, resolution of recombination intermediates, rDNA maintenance, and ribosome biogenesis. The gene has been connected to auxin signaling, stem cell proliferation, and root development. Localisation evidence places the product in the nucleus, cytoplasm, spindle pole body, and division septum. Phenotypic associations include abnormal chromosome segregation, decreased viability, inviability, decreased vegetative growth, increased heat sensitivity, decreased UV resistance, and decreased competitive fitness.