HST1 — Saccharomyces cerevisiae S288c

Summary

YOL068C in Saccharomyces cerevisiae S288c encodes a NAD-dependent histone deacetylase, a sirtuin family protein with activity on histones H3K4, H3K9, H3K14, and H4K16, as well as general protein deacetylase activity and NAD+ binding. This gene is associated with protein deacetylation, regulation of NAD metabolism, adaptive thermogenesis, mitophagy, anti-apoptosis, biofilm formation, and detoxification of arsenic. It is linked to chromatin and heterochromatin regions including subtelomeric, rDNA, and mating-type region heterochromatin, as well as the SET3C complex, nucleus, and cytoplasm. Phenotypic associations include increased silencing, decreased telomere length, altered stress resistance (both increased and decreased oxidative stress resistance), increased heat sensitivity, altered competitive fitness, and changes in chemical compound excretion and toxin resistance.