RAS1 — Saccharomyces cerevisiae S288c

Summary

YOR101W, also known as RAS2 in Saccharomyces cerevisiae S288c, encodes a small GTPase of the Ras-type family that binds GTP, GDP, CTP, and UTP and exhibits GTPase and G protein activity. The gene is associated with Ras protein signal transduction, response to nutrients, cellular response to glucose stimulus, invasive and filamentous growth, upregulation of growth, apoptosis, mating projection assembly, and phenotypic switching. It is also linked to cytoskeleton organization, cell-substrate adhesion, protein farnesylation, and AMP anabolism. Localization evidence places the product at the plasma membrane, division septum, cell cortex, and mating projection structures. Phenotypic associations include increased invasive growth, altered replicative and chronological lifespan, abnormal vacuolar morphology, and changes in metal and chemical resistance. Studies of related genes in other species link the family to reduced virulence.