DED1 — Saccharomyces cerevisiae S288c

Summary

YOR204W, also known as DED1, encodes a DEAD-box RNA helicase with ATP hydrolase activity, translation initiation factor activity, RNA strand annealing activity, and eIF4G and G-quadruplex binding. In Saccharomyces cerevisiae, this gene is associated with cytoplasmic translational initiation, spliceosome complex disassembly, RNA splicing, transport, and processing, as well as strand displacement, RNP complex assembly, retrotransposition, and DNA damage response. It is linked to stress granule and spliceosome complex localisation, and to negative regulation of cytoplasmic translational initiation in response to stress. Associations with traits include sugar content and oxidative stress, and with phenotypes such as increased cold sensitivity, altered toxin resistance, decreased vegetative growth, and increased transposable element transposition. Related genes in other species link the family to RNA helicase activity (EC 3.6.4.13).