NUD1 — Saccharomyces cerevisiae S288c

Summary

YOR373W in Saccharomyces cerevisiae S288c encodes a protein with signaling adaptor activity, belonging to the CDIRP and leucine-rich repeat (LRR) domain superfamily. The gene is associated with a wide range of cell cycle processes, including astral microtubule organization, spindle positioning, spindle checkpoint function, mitotic and meiotic exit, cytokinesis, anaphase, metaphase, G1 phase, centrosome duplication, and cell cycle control. It is also linked to protein import, transport, secretion regulation, signal transduction, anatomical structure development, and spore formation. The protein localizes to the mitotic spindle pole body and its outer plaque, as well as the cytoplasm and macromolecular complexes. Phenotypic associations include abnormal spindle, cytoskeleton, and actin morphology, cell cycle arrest in anaphase, abnormal nuclear position and chitin deposition, decreased viability and sporulation efficiency, altered protein accumulation and distribution, increased heat sensitivity, and altered chemical resistance. Related genes in other species link the family to similar cell cycle functions.