RLM1 — Saccharomyces cerevisiae S288c

Summary

YPL089C from Saccharomyces cerevisiae S288c encodes a MADS-box transcription factor of the MEF2-like family, possessing RNA polymerase II-specific DNA-binding transcription activator activity and protein dimerization activity. The protein localises to the nucleus, chromatin, nuclear envelope and cytosol, and is a component of the M/G1 phase-specific MADS box-forkhead transcription factor complex. YPL089C is associated with cell wall modification, flocculation, cell adhesion, cell quiescence, detoxification, endocytosis, vesicle transport, sulfite efflux, autolysis, cell death, and responses to cadmium, manganese and miconazole. It has been linked to numerous phenotypes including altered stress resistance, decreased vegetative growth, abnormal vacuolar morphology, increased competitive fitness, decreased UV resistance, and changes in chemical and toxin resistance. Studies of related genes in other species link the family to loss of pathogenicity.