ATG5 — Saccharomyces cerevisiae S288c

Summary

YPL149W (ATG5) on chromosome XVI of Saccharomyces cerevisiae encodes a protein with cargo receptor ligand activity, APG8 ligase activity, and enzyme activator activity. It contains Atg5_HR, ATG5_HBR, and ubiquitin-like domains. ATG5 is associated with macroautophagy, mitophagy, ER-phagy, aggrephagy, and autophagic cell death, as well as response to starvation, protein lipidation, vesicle formation, meiotic cell cycle, cell differentiation, and membrane depolarization. It localizes to the phagophore assembly site (PAS), Atg12-Atg5-Atg16 complex, phagophore membrane, mitochondria-associated membrane, vacuole-IM contact site, cytosol, and nucleus. The gene is linked to decreased viability, absent sporulation, increased chronological lifespan, decreased desiccation resistance, abnormal vacuolar and nuclear morphology, and decreased competitive fitness.