MEX67 — Saccharomyces cerevisiae S288c

Summary

YPL169C in Saccharomyces cerevisiae S288c encodes a member of the NXF family of nuclear export factors, containing Mex67_RRM, TAP_C, NTF2-like and UBA-like domains. The protein binds U1, U2, U4, U5 and U6 snRNAs, tRNA and RNA generally, and is associated with nuclear and cytoplasmic RNA surveillance, mRNA transport, RNA breakdown, ribosome assembly and biogenesis, tRNA nuclear import and re-export, ribosomal subunit export from the nucleus, and posttranscriptional gene expression. It localises to the TAP-p15 complex, nuclear pore complex, nucleolus, cytoplasm, cytosol and nucleus. The gene is linked to oxidative stress, and phenotypes include decreased nuclear export, abnormal RNA modification and accumulation, decreased nucleolar size and cell size, increased innate thermotolerance, decreased toxin resistance, heat sensitivity, haploinsufficiency, decreased competitive fitness, and altered chemical resistance. Studies of related genes in other species link the family to similar RNA transport functions.