SAR1 — Saccharomyces cerevisiae S288c

Summary

YPL218W in Saccharomyces cerevisiae S288c encodes a small GTPase of the SAR1 type, possessing GTPase activity and GTP binding. The gene is associated with mitochondrial fusion, vesicle formation and organization, protein transport, and regulation of COPII vesicle coating. It is linked to the endoplasmic reticulum exit site, COPII vesicle coat, Golgi membrane, and mitochondria-associated membrane. YPL218W has been connected to abnormal endoplasmic reticulum, nuclear, and mitochondrial morphology, absent respiratory growth, increased protein accumulation, decreased competitive fitness, reduced chemical resistance, and inviability. The gene is also associated with interphase, body morphogenesis, response to DTT, and positive regulation of protein exit from the ER. Related genes in other species link it to GTPase activity (EC 3.6.5.-).