SUA7 — Saccharomyces cerevisiae S288c

Summary

YPR086W, also known as SUA7, encodes a TFIIB family protein in Saccharomyces cerevisiae S288c. The product contains a zinc-finger TFIIB domain and cyclin-like domains, and it exhibits TBP-class protein binding and general transcription factor 2 (GTF2) activity. It localises to the nucleus and the transcription preinitiation complex, and is associated with transcription initiation from RNA polymerase II promoters, preinitiation complex assembly, and transcriptional start site selection. YPR086W is also linked to translation initiation, mRNA processing, DNA repair, cell cycle progression, cell growth, and fermentation. The gene has been associated with responses to heat and oxidative stress, phospholipid anabolism, and memory. Phenotypic associations include increased cold and heat sensitivity, decreased oxidative stress and toxin resistance, reduced vegetative growth, and inviability, as well as increased competitive fitness and altered chemical resistance.