CTF4 — Saccharomyces cerevisiae S288c

Summary

YPR135W (CTF4) on chromosome XVI of Saccharomyces cerevisiae S288c encodes a chromatin-binding protein containing WD40 repeats and a Ctf4-like C-terminal domain. The gene is associated with plasmid maintenance, sister chromatid cohesion, nucleosome assembly, DNA metabolism, lagging strand initiation, telomere maintenance, and the spindle assembly checkpoint. It has been linked to cell cycle progression through G1/S and S phase, chromosome segregation, mitotic recombination, and transposable element transposition. Phenotypic associations include decreased viability, altered cellular and nuclear morphology, increased mutation frequency, reduced fermentative and respiratory growth, decreased freeze-thaw and UV resistance, and decreased hyperosmotic stress resistance. The protein localises to heterochromatin, the nuclear replication fork, nucleoplasm, and chromatin. Studies of related genes in other species link the family to similar processes.