SCEI — Saccharomyces cerevisiae S288c

Summary

SCEI (Q0160) in Saccharomyces cerevisiae S288c, located on the mitochondrial chromosome, encodes a protein with cytochrome-c oxidase activity, endonuclease activity, and heme binding. It is a member of the LAGLIDADG_2 and homing endonuclease families and is associated with mitochondrial respiratory chain complex IV. The gene is linked to a wide range of biological processes, including intron homing, group II intron splicing, DNA integration, long tract gene conversion, meiotic gene conversion, regulation of double-strand break repair, regulation of NHEJ, resolution of recombination intermediates, protein splicing, DNA modification, DNA deamination, antigenic variation, class switching, V-J joining, axonal transport, skeletal development, regulation of protein folding, and sex determination. It has also been connected to oxidative stress. Studies of related genes in other species link the family to endonuclease activity.