COX2 — Saccharomyces cerevisiae S288c

Summary

Q0250 (COX2) is a mitochondrial gene in Saccharomyces cerevisiae S288c that encodes cytochrome-c oxidase subunit 2, a copper-binding component of respiratory chain complex IV. The gene is associated with mitochondrial electron transport from cytochrome c to oxygen, ATP synthesis coupled electron transport, OXPHOS, and heme A anabolism. It has been connected to mitochondrial inner membrane localisation, mitochondrial translation initiation, transcription, and inheritance, as well as signal peptide processing, tropism, glucoside transport, NADP metabolism, alanine metabolism, the GABA shunt, glycogen anabolism, and genetic transfer. The gene is linked to the trait of oxidative stress, and its disruption is associated with absent respiratory growth and decreased oxidative stress resistance. Studies of related genes in other species assign the family to EC 7.1.1.9 (cytochrome-c oxidase).