CNE1 — Saccharomyces cerevisiae S288c

Summary

YAL058W in Saccharomyces cerevisiae S288c encodes a calreticulin/calnexin family protein with sugar binding, unfolded protein binding and calcium ion binding activities. The gene is associated with glycosylation, protein prenylation, cytokinesis, DNA amplification, morphogenesis, beta-glucan anabolism, signal transduction, germ tube formation, ER membrane biogenesis, the cell integrity MAPK cascade, cell death, regulation of lipogenesis, chlamydospore formation, and arginine metabolism. It localises to the ER membrane and fungal-type vacuole. Phenotypic associations include increased chitin deposition, abnormal ER morphology, increased killer toxin resistance, altered UV and heat sensitivity, increased oxidative stress resistance, decreased chronological and increased replicative lifespan, decreased vegetative growth and competitive fitness, and altered chemical resistance. Studies of related genes in other species link the family to pathogenicity.