TEL1 — Saccharomyces cerevisiae S288c

Summary

YBL088C, also known as TEL1 on chromosome II of Saccharomyces cerevisiae S288c, encodes a protein with serine/threonine kinase activity, ATP binding, and phosphatidylinositol-4-phosphate binding, and it belongs to the PI3/4-kinase-related protein family. The gene is associated with telomere binding, telomere capping, and telomere maintenance, as well as with replicative senescence, the DNA damage checkpoint effector process, and regulation of meiotic DNA double-strand break formation. It is linked to telomeric silencing, sumoylation, polyphosphate signaling, and apoptotic processes. Phenotypically, TEL1 is connected to decreased telomere length, increased transposable element transposition, decreased chronological lifespan, and reduced resistance to oxidative stress, UV, acid pH, metals, and heat. It is also associated with decreased colony size, delayed G2/M phase transition, and altered competitive fitness. Studies of related genes in other species link the family to protein serine/threonine kinase activity (EC 2.7.11.1).