POL30 — Saccharomyces cerevisiae S288c

Summary

YBR088C in Saccharomyces cerevisiae S288c encodes a processivity clamp that binds DNA. The gene product is localized to the PCNA complex, nuclear replication fork, nucleoplasm, chromatin, and cytosol, and is associated with bypass DNA synthesis, postreplication repair, nucleotide metabolism, mismatch repair, nucleotide excision repair, double-strand break repair, mitotic recombination, gene conversion, chromatin silencing, sumoylation, and the DNA damage checkpoint. YBR088C is linked to abnormal meiotic recombination, increased mitotic recombination, decreased silencing, increased mutation frequency, decreased UV resistance, increased heat sensitivity, decreased vegetative growth, and altered chemical resistance. Studies of related genes in other species further connect the family to DNA replication and repair functions.