CDC28 — Saccharomyces cerevisiae S288c

Summary

YBR160W (CDC28) on chromosome II of Saccharomyces cerevisiae S288c encodes a cyclin-dependent protein kinase with CDK activity, protein serine/threonine kinase activity, cyclin binding, RNAP II core binding, histone binding, and ATP binding. It is a member of the CDK family containing a protein kinase domain. CDC28 is associated with mitotic cell cycle regulation, cell division, cell size control, morphogenesis, actin cytoskeleton organization, spindle organization, chromatin organization, chitin anabolism, lipolysis, cellular homeostasis, nuclear transport, the stringent response, plasmid maintenance, the septin checkpoint, and responses to glucose and heat. It localizes to the CDK holoenzyme, serine/threonine protein kinase complex, Pho85-Pho80 CDK-cyclin complex, meiotic spindle, spindle pole bodies, and telomeric repeat regions. The gene is linked to traits including protein content and oxidative stress, and phenotypes such as cell cycle arrest, abnormal cell size and shape, altered budding patterns, decreased viability and sporulation, increased cold sensitivity, and abnormal actin cytoskeleton morphology.