SNF5 — Saccharomyces cerevisiae S288c

Summary

YBR289W (SNF5) on chromosome II of Saccharomyces cerevisiae encodes a transcriptional co-regulator that binds nucleosomes and is a core component of the SWI-SNF and PBAF chromatin-remodelling complexes. The gene is associated with chromatin remodelling at centromeres, regulation of nuclear cell cycle DNA replication, double-strand break repair, homologous recombination, and viral transcription. It is linked to the glucose effect, response to carbon starvation, quorum sensing, cell aggregation, regulation of cell growth, morphogenesis, signal transduction, and protein folding. Associations with traits include acid sensitivity and oxidative stress. Phenotypic connections include decreased resistance to freeze-thaw, alkaline pH, UV, hyperosmotic stress, desiccation, and starvation; decreased chronological lifespan; decreased vegetative and respiratory growth; abnormal sporulation and cell size; and altered carbon and nitrogen source utilisation.