PGK1 — Saccharomyces cerevisiae S288c

Summary

YCR012W in Saccharomyces cerevisiae S288c encodes phosphoglycerate kinase, an enzyme with phosphoglycerate kinase activity that binds ADP, ATP and metal ions. This gene is associated with glycolytic fermentation and the glycolytic process, as well as ethyl acetate metabolism, cellobiose transport, catabolite repression, starch breakdown, reactive oxygen species metabolism, pexophagy, glycophagy, arginine breakdown, valine biosynthesis, and regulation of mRNA stability. It has been linked to traits including respiration rate, biomass yield, and oxidative stress. Phenotypic associations include decreased fermentative growth and metabolism, increased exponential phase growth rate, increased filamentous growth, absent invasive growth, decreased carbon source utilization, abnormal chromosome maintenance, decreased starvation and toxin resistance, inviability, haploinsufficiency, altered vegetative growth rate, and altered chemical resistance. The protein localises to the cytoplasm, plasma membrane, cell wall, extracellular region, mitochondria, and biofilm matrix.