RAD18 — Saccharomyces cerevisiae S288c

Summary

YCR066W (RAD18) on chromosome III of Saccharomyces cerevisiae S288c encodes a protein with RING-finger ubiquitin ligase activity, ssDNA-dependent ATPase activity, ssDNA binding and zinc-binding properties. The protein localises to chromatin and the nucleus. RAD18 is associated with postreplication repair, recombinational repair, nucleotide excision repair, base excision repair, mismatch repair, DNA recombination, gene conversion, meiotic heteroduplex formation, and DNA metabolism. It is also linked to ubiquitin-dependent protein catabolism via the multivesicular body sorting pathway, sumoylation, protein modification, transsulfuration, and aromatic amino acid family anabolism. The gene has been connected to numerous phenotypes including decreased UV and X-ray resistance, increased mutation frequency, decreased vegetative growth and competitive fitness, increased heat sensitivity, and altered resistance to chemicals and oxidative stress.