MPS1 — Saccharomyces cerevisiae S288c

Summary

YDL028C (MPS1) on chromosome IV of Saccharomyces cerevisiae S288c encodes a dual-specificity protein kinase with MAPKK, MEKK, and CDK activities, along with protein serine/threonine kinase and tyrosine kinase functions, and it binds ATP, metals, and phospholipids. The gene is associated with mitotic and meiotic chromosome segregation, spindle assembly and checkpoint control, centrosome duplication, the MAPK cascade, and protein phosphorylation. It localizes to the Pho85-Pho80 CDK-cyclin complex, vacuole-IM contact sites, the ULK complex, phagophore, septin ring, and bud neck. Associations include increased polyploidy, decreased exponential-phase growth, M-phase arrest, abnormal budding, chromosome segregation, spindle morphology, and actin cytoskeleton, as well as altered stress resistance, viability, and competitive fitness. The gene is also linked to protein content and oxidative stress traits.