USO1 — Saccharomyces cerevisiae S288c

Summary

YDL058W, also known as USO1 in Saccharomyces cerevisiae S288c, encodes a protein associated with the Golgi stack and COPII-coated vesicle membrane. The gene product is linked to vesicle docking, fusion, and targeting, as well as protein secretion and transport between the ER and Golgi. YDL058W is associated with multiple biological processes including intra-Golgi transport, mitotic checkpoint, rRNA transcription, and response to oxidative stress. Phenotypic associations include abnormal cytoskeleton, nucleolar, and vacuolar morphology, decreased protein secretion, reduced oxidative stress resistance, and inviability or haploinsufficiency when disrupted. The gene is also linked to vegetative growth rate and competitive fitness. Studies of related genes in other species link the family to similar vesicle trafficking functions.